Iron Metabolism Abnormalities in Children with Homozygous Sickle Cell Disease in Brazzaville

Introduction: Sickle cell disease is the most common genetic in world, particularly sub-Saharan Africa. It a protean condition with multiple complications including disturbed iron metabolism. Objectives: To determine prevalence of metabolism abnormalities children homozygous sickle disease, to describe epidemiological, clinical and paraclinical characteristics these identify associated factors. Patients Methods: This was cross-sectional analytical study conducted over 9 months mother-child consultation unit Brazzaville University Hospital, National Reference Centre for Cell Disease paediatric department Blanche Gomes hospital. concerned aged between 3 15 years followed up disease. The based on haemogram, test, LDH, transaminases CRP. Results: overall abnomalities 40.7%. Of 145 included, 35.9% had overload 4.8% deficiency. Iron infections, undernutrition, supplementation number blood transfusions. deficiency not significantly any factor but recurrent infections were relatively more frequent. Conclusion: Abnormalities patients are frequent, which justifies monitoring during follow-up early detection better management.